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REFLECTIONS
Dyslipidaemia
Dyslipidaemia Global Newsletter #10 2025

RISK ASSESSMENT AND PREVENTION Dyslipidaemia

6. Coronary atherosclerosis screening in asymptomatic adults using coronary artery calcium for cardiovascular
prevention: A systematic review of randomised controlled trials and prospective cohorts. Scheu V, et al. BMJ Open.
2025 Jul 5;15(7):e101472.
7. Impact of LDL-cholesterol when the coronary artery calcium score is 0: Long-term cardiovascular events. Peng AW,
et al. J Am Coll Cardiol. 2025 Sep 2;86(9):676-680.

8. Low-density lipoprotein cholesterol and cardiovascular risk in the absence of calcifications on computed
tomography: The Western Denmark heart registry. Andersen MH, et al. Eur Heart J. 2025 Aug 9:ehaf497. doi: 10.1093/
eurheartj/ehaf497. Online ahead of print.

TREATMENT AND THERAPEUTICS

9. ApoB-containing lipoproteins: Count, type, size, and risk of coronary artery disease. Morze J, et al. Eur Heart J. 2025
Jul 14;46(27):2691-2701.
10. Choosing the optimal nonstatin lipid lowering therapies for statin-intolerant patients: A systematic review and
network meta-analysis. Laohapiboolrattana W, et al. J Clin Lipidol. 2025 Aug 5:S1933-2874(25)00352-6. doi: 10.1016/j.
jacl.2025.07.012. Online ahead of print.
11. Effect of lipid-lowering therapies on lipoprotein(a) levels: A comprehensive meta-analysis of randomized controlled
trials. Xie S, et al. Atherosclerosis. 2025 Sep;408:120420.

12. Pelacarsen: Mechanism of action and Lp(a)-lowering effect. Bhatia HS, et al. J Clin Lipidol. 2025 Jun 16:S1933-
2874(25)00322-8. doi: 10.1016/j.jacl.2025.06.004. Online ahead of print.

SPECIAL POPULATIONS

13. Extreme lipoprotein(a) is a cardiovascular risk equivalent in heterozygous familial hypercholesterolemia. Paquette
M, et al. J Clin Lipidol. 2025 Aug 13:S1933-2874(25)00372-1. doi: 10.1016/j.jacl.2025.08.009. Online ahead of print.

14. Lipoprotein(a) and risk of dementia: Findings from three cohort studies. Thomas PE, et al. Eur Heart J. 2025 Aug
18:ehaf465. doi: 10.1093/eurheartj/ehaf465. Online ahead of print.

15. Statin use in pregnancy and risk of congenital malformations: A Norwegian nationwide study. Christensen JJ, et al.
Eur Heart J. 2025 Aug 21:ehaf592. doi: 10.1093/eurheartj/ehaf592. Online ahead of print.

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